Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases
نویسندگان
چکیده
منابع مشابه
Prospect of Induced Pluripotent Stem Cell Genetic Repair to Cure Genetic Diseases
In genetic diseases, where the cells are already damaged, the damaged cells can be replaced by new normal cells, which can be differentiated from iPSC. To avoid immune rejection, iPSC from the patient's own cell can be developed. However, iPSC from the patients's cell harbors the same genetic aberration. Therefore, before differentiating the iPSCs into required cells, genetic repair should be d...
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The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
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ژورنال
عنوان ژورنال: Stem Cells International
سال: 2012
ISSN: 1687-966X,1687-9678
DOI: 10.1155/2012/498197